adiponectin: an adipokine with protective features against metabolic syndrome
نویسندگان
چکیده
metabolic syndrome (mets) as a collection of obesity-associated disorders is associated with inflammation, oxidative stress, pro-thrombotic state, elevated risk of developing cardiovascular disease and type 2 diabetes. adiponectin is one of the most abundant peptide hormones derived from adipose tissue. this protein plays a major role in glucose and lipid metabolism and prevents development of vascular changes. anti-oxidative and anti-inflammatory effects are the other features of adiponectin. hypoadiponectinemia is associated with hypertension and pro-thrombotic state. in this review, we discuss the crucial role of adiponectin in prevention of metabolic syndrome considering its effects on the components of this syndrome. pharmacological interventions and lifestyle modification may increase plasma adiponectin level or tissue sensitivity which seems to be a promising target for prevention and therapeutic approaches of mets and related diseases.
منابع مشابه
Adiponectin: an adipokine with protective features against metabolic syndrome
Metabolic syndrome (MetS) as a collection of obesity-associated disorders is associated with inflammation, oxidative stress, pro-thrombotic state, elevated risk of developing cardiovascular disease and type 2 diabetes. Adiponectin is one of the most abundant peptide hormones derived from adipose tissue. This protein plays a major role in glucose and lipid metabolism and prevents development of ...
متن کاملAdiponectin: an adipokine with protective features against metabolic syndrome
Metabolic syndrome (MetS) as a collection of obesity-associated disorders is associated with inflammation, oxidative stress, pro-thrombotic state, elevated risk of developing cardiovascular disease and type 2 diabetes. Adiponectin is one of the most abundant peptide hormones derived from adipose tissue. This protein plays a major role in glucose and lipid metabolism and prevents development of ...
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In this review article, the crucial roles of adipocytes in the development of so-called metabolic syndrome and vascular disease are reviewed, focusing on adipocyte-derived bioactive substances, adipocytokines. Recent progress in adipocyte biology shows that adipocytes are not merely energy-storing cells but that they secrete a variety of hormones cytokines, growth factors, and other bioactive s...
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عنوان ژورنال:
iranian journal of basic medical sciencesجلد ۱۸، شماره ۵، صفحات ۴۳۰-۴۴۲
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